Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD).A surprising paradox emerging from recent studies is that ubiquitin ligases (E3s) and Toaster deubiquitinases (DUBs), enzymes wit
Dash Parts and Interior Accessories Given the global dominance of American movies, they play a significant role in presenting U.S.ideology and culture to the world, thus raising concern of undermining domestic culture.This paper investigates whether trade shapes culture by studying the impact of imported American movies on Chinese cultural values m
Insular organisms often evolve predictable phenotypes, like flightlessness, extreme body sizes, or increased melanin deposition.The evolutionary forces and molecular targets mediating these patterns remain mostly unknown.Here we study the Chestnut-bellied Monarch (Monarcha castaneiventris) from the Solomon Islands, a complex of closely related subs
Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways.Recent research has displayed a deep interest in developing plant-based cancer therapeutics for better management of the disease and limited side effects.A wide range of plant-derived compounds have been reported for their anticancer potential in the quest of find